At the moment I have only a stereo I/O PC-soundcard, but my Akai has 8 indiv. outs. I run Cubase VST on my PC but hate to mix & EQ internally. Since the song (audio + MIDI) I worked on was based on repeating guitar & bass parts (together with sequenced drumhits from the sampler), I had enough sampler memory to be able to transfer all wavs from Cubase to my S2000 (using the export-segment-feature of Cubase and then to the Akai using Millenium). I made a multi & programs, assigned the various sounds to indiv. outs (be sure to set all samples to one-shot), added MIDI-triggers in Cubase and there I got all my wavs, but now coming from my sampler and on separate mixer channels ! A multi I/O soundcard is definitely more convenient here, but if you still only have a stereo card (like me) and hate to mix by mouse, then the above might be an idea.